Dr. MERT ERKAN

Education

• 2017Professor of General Surgery, Koç University
• 2014ÜAK Associate Professorship Equivalency
• 2011Associate Professor of General Surgery, Technical University of Munich, Klinikum rechts der Isar
• 2010Digestive System Surgery Specialization Technical University Munich, Klinikum rechts der Isar
• 2007PhD, University of Heidelberg: Summa cum laude (Summa cum laude). Thesis: The influence of tumor modulated microenvironment on pancreatic cancer behavior.
• 2001Istanbul University Istanbul Faculty of Medicine General Surgery
• 2001General Surgery Specialist, Istanbul University, Istanbul Faculty of Medicine, Thesis: Retrospective evaluation of patients treated with the diagnosis of iatrogenic biliary injury
• 1995Istanbul University Istanbul Faculty of Medicine

Experience

• 2021Acıbadem Health Group
• 2014 – 2021Koç University Faculty of Medicine Research Laboratory
• 2014 – 2021Koç University Faculty of Medicine
• 2021Pancreatic Cancer Research Center, Acıbadem Mehmet Ali Aydınlar University Istanbul Türkiye
• 2017 – 2021Koç University Translational Medicine Research Center
• 2017 – 2021Koç University Health Sciences Institute
• 2007 – 2014Pancreas Research Center, Technical University of Munich
• 2007 – 2014Technical University of Munich, Isar Clinic
• 2003 – 2007University of Heidelberg, Department of General Surgery
• 2003 – 2007European Pancreas Research Center, University of Heidelberg
• 2001 – 2003Istanbul University, Istanbul Faculty of Medicine, HPB Surgery Unit
• 1995 – 2001Istanbul University, Istanbul Faculty of Medicine

Memberships

• European Digestive Surgery/ EDS 2003-
• The European Consortium on Minimally Invasive Pancreatic Surgery
• Istanbul Chamber of Medicine 1995-2021
• Europan/African Hepato-Pancreato-Biliary Association Scientific and Research Committee Member: 2014 – Halen / Program committee: 2015 – 2019 / Pancreatic terminology committee founding member 2021 –
• Bursa Medical Chamber 2021
• German Society for General and Visceral Surgery (DGAV) 2007 – 2014
• European Pancreatic-Club/ EPC 2003-
• German Pancreas Club/ DPC 2003-
• Turkish Hepato-Pancreato-Biliary Surgery Association: 1998 Board Member: 2015-2017
• International Hepato-Pancreato-Biliary Association (IHPBA) 2001-
• International Association of Pancreatology (IAP) 2003-

PUBLICATIONS

• Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.Karpathaki, Marlena Kowalska, Ezgi Kaya-Aksoy, Liang Song, Eveline A Zeeuw van der Laan, María P López-Alberca, Marc Nazaré, Maximilian Reichert, Diet DA Ruess, GJ Heynen, KJ Ciecielski, J Ai, A Berninger, D Kabacaoglu , Kivanc Görgülü, Zahra Dantes, Sonja M Wörmann, Kalliope N Diakopoulos, Angeliki F
• Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.Aayush Gupta, Irina Heid, Peter B Noël, Rickmer Braren, Mert Erkan,Nature medicine 2015 (280) PK Mazur, A Herner, SS Mello, M Wirth, S Hausmann, FJ Sánchez-Rivera, Shane M Lofgren, Timo Kuschma, Stephan A Hahn, Deepak Vangala, Marija Trajkovic-
• Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.Manuel Hidalgo, Mert Erkan, …Nature methods 2014 (165) I Miranda-Lorenzo, J Dorado, E Lonardo, S Alcala, AG Serrano, Jenifer Clausell-Tormos, Michele Cioffi, Diego Megias, Sladjana Zagorac, Anamaria Balic,
• The role of stroma in pancreatic cancer: diagnostic and therapeutic implications.Nature reviews Gastroenterology & hepatology 2012 (476) M Erkan, S Hausmann, CW Michalski, AA Fingerle, M Dobritz, J Kleeff.
• StellaTUM: current consensus and discussion on pancreatic stellate cell research.Gut 2011 (365) M Erkan, G Adler, MV Apte, MG Bachem, M Buchholz, S Detlefsen, .
• Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinomaNeoplasia 2009 (294) M Erkan, C Reiser-Erkan, CW Michalski, S Deucker, D Sauliunaite,
• Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissuesNature protocols 2009 (162) S Streit, CW Michalski, M Erkan, J Kleeff, H Friess.
• The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma.Clinical gastroenterology and hepatology 2008 (374) M Erkan, CW Michalski, S Rieder, C Reiser Erkan, I Abiatari, A Kolb
• Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery.Annals of surgery 2008 (592) N Hüser, CW Michalski, M Erkan, T Schuster, R Rosenberg, J Kleeff.
• Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity.Gastroenterology 2007 (330) M Erkan, J Kleeff, A Gorbachevski, C Reiser, T Mitkus, I Esposito, T Giese
• The neurotrophic factor artemin promotes pancreatic cancer invasion.Annals of surgery 2006 (159) GO Ceyhan, NA Giese, M Erkan, AG Kerscher, MN Wente, T Giese
• Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis.Oncogene 2005 (221) M Erkan, J Kleeff, I Esposito, T Giese, K Ketterer, MW Büchler, NA Giese, …